ELEVATED PLATELET-DERIVED GROWTH FACTOR-BB CONCENTRATIONS IN PREMATURE NEONATES WHO DEVELOP CHRONIC LUNG DISEASE

Abstract Background Chronic lung disease (CLD) in the preterm newborn is associated with inflammation and fibrosis.Platelet-derived growth factor-BB (PDGF-BB), a potent chemotactic growth factor, may mediate the fibrotic component of CLD.The objectives of this study were to determine if tracheal aspirate (TA) concentrations of PDGF-BB increase the

Both TRPA1 and purinergic P2X receptors have been proposed as potential targets for the treatment of visceral pain.We found that the intracolonic administration of a low dose mustard oil (0.5%), a well-known TRPA1 agonist, produced nociceptive responses and abdominal wall referred mechanical hyperalgesia, without inducing apparent tissue damage.Bot